Journal of Materials Science and Engineering with Advanced TechnologyAuthor's: Mai A. El-Didamoony, Mohamed E. Elsadek, Mohamed M. Baraka, Samy M. Ibrahim and Mahmoud M. Sebaiy
Pages: [1] - [22]
Received Date: April 27, 2020
Submitted by:
DOI: http://dx.doi.org/10.18642/jmseat_7100122129
A new spectrophotometric method is described for determination of
irbesartan, losartan and bisoprolol in bulk and pharmaceutical dosage
forms using insitu generated bromine as oxidizing agent and rhodamine
B as chromogenic agent. Drugs are treated with known excess of bromine
and residual unreacted bromine is determined by treating with fixed
amount of rhodamine B then measuring absorbance at 557nm. The amount
of bromine reacted corresponds to the amount of each drug. Effect of
acidity, bromate-bromide volume and reaction time, on the absorption
were studied. Calibration curves were linear over ranges of 
and 
for irbesartan, losartan, and bisoprolol,
respectively. The method was satisfactory applied for the
determination of drugs in both bulk and pharmaceutical forms and
results were compared statistically with reference methods.
spectrophotometric, irbesartan, losartan, bisoprolol, rhodamine B.
