Journal of Materials Science and Engineering with Advanced TechnologyAuthor's: Hang Dang Thi Le, Duong Van Thuy, Minh Dung Truong, Quyen Tran Ngoc, Ha Tran Bao Le, Hoa Nguyen Khanh, Khoa Nguyen Cuu and Phuong Nguyen Thi
Pages: [19] - [38]
Received Date: July 6, 2016
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DOI: http://dx.doi.org/10.18642/jmseat_7100121684
In this study, hydrogel composites based biphasic calcium phosphate (BCP), gelatin, and oxidized alginate were fabricated by Schiff-base reaction. Nanoparticles BCP were loaded into hydrogel to improve the ability of bio-mineralization and cell adhesion. The formation of apatite from hydrogel composites in stimulated body fluid (SBF) were characterized by energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD). In vitro study with bone marrow mesenchymal stem cells (MSCs) evidenced that cells were well-attached on hydrogel composites. Moreover, micro-CT data showed that hydrogel composites have bone surface/volume ratio and bone surface density higher than hydrogel. The obtained results indicated that the hydrogel composite could be a potential material for bone regeneration.
gelatin, oxidized alginate, BCP, hydrogel composite.
